What is my solution:
https://www.aopa.org/news-and-media/all-news/2007/august/01/north-american-aviation-p-51d-mustang
The original P-51D Mustang flight manual, AN 01-60JE-1, states that the maximum recommended flight speed with the canopy open is 130 knots (approx. 240 km/h). Exceeding this speed can result in damage to the canopy or its detachment.
On this page you can read about the experience of an A-10 and RAF Typhoon pilot. Both aircraft lost their cockpit canopy and it says:
Major Brett DeVries of the U.S. Air Force, whose A-10 Thunderbolt II shed its canopy following a gun malfunction in 2017, said that the strength of the air rushing past was strong enough to pin his head back against the headrest – as if he had been punched. He chose to lower his seat as far as it would go in an attempt to mitigate the issue.
So here you see that the airflow also affects the pilot physically.
Here is written about the strength of the wind too
https://www.atsb.gov.au/publications/safety-advisory-notice/ao-2014-164-san-012
Here it is written about the crash of an RV-6A aircraft in which the cockpit opened during flight and the wind flow changed the aerodynamics of the aircraft so that the aircraft was not controllable and the aircraft crashed. From which it follows that if an aircraft opens the cockpit in flight, and is not adapted to fly with an open cockpit, it can become uncontrollable.
The best example to show that even the slightest change to an aircraft will cause a big change in the aerodynamic properties of the aircraft, than on gliders, where this issue is very widely addressed. On this page you will learn what the effect of the gap between the cabin canopy and the fuselage is. 1mm is a gap at which there is an immeasurable violation of the aerodynamics of the aircraft. 3mm and more is the limit when there is a significant change in the flight properties of the aircraft, which mainly increase resistance.
The conclusion from this source is that opening the cabin canopy will increase the drag many times over.
This page is the story of a person whose cockpit opened during flight and was exposed to the full force of the wind, the plane did not have a front shield so the wind force was at full force.
Aircraft:Extra 330LX
Cruise Speed: Approximately 158 knots (about 182 mph or 293 km/h)
The result, as commented on by the person in the incident, is: “The flight was a distressing experience, filled with noise, breathing difficulties, and impaired visibility. It took me nearly 28 hours to fully recover my vision."
So my conclusion is: the pilot when flying with an open cockpit is affected by pressure, temperature, noise, wind gusts and interference with the controls. I will leave the specific speeds and influencing the player in the game to the developers, but a simple list of effects: vision shaking, blurred vision, reduced controllability or interference with the controls and when flying at high altitude or climbing quickly, black out due to a sharp change in pressure and of course increased air resistance