Which is doing more damage and which is more giving point between small but numerical bombs or single powerful bomb

as the title said, which is more doing damage and which is giving more point, small but numerical bombs or single powerful bomb. Is TNT equivalent the only calculation factor?

I noticed I get more points and more damage with a 250/1000/250 loadout instead of a 500/500/500.

In the past I’ve noticed you can kill bases with less total TNT if you use more, but smaller, bombs. I thought TNT equivalent would be all that matters, but it seems the calculation is a little more realistic than that.

Hard to give specific advice for all situations, but if you know roughly how much TNT is needed to kill a base at any EC level, you have a starting point for experimenting with loadouts in a particular aircraft in order to find the best or most efficient bomb load.