More than enough to annihilate an entire armored column when its loaded with GBU-53/Spice 250 racks.
This question has been asked so many times online as a sort of gotcha against the F-35. And the answer has always been the same. Because you’d end up spending more money. With the F-15E, you need some CAP escort, some SEAD to go along with it, probably some stealth fighters for deep strikes, and so on. So when you’re sending it somewhere where it would face a decent opponent, you need a whole lot of other squadrons coming alongside it and all the maintenance, fuel, etc. It’s expensive and a logistical nightmare.
With only 1 F-35 Squadron, you can do all of these missions progressively, ranging from deep CAS in stealth configuration to radar hunting, to CAP, to heavy CAS once the AA is dead.
US mains will always say the F-22 will win easily. But reality is that its probably quite close, but in-game that wont matter, because US mains are terrible and will probably still have a bad K/D with it