In recent update, we have Israeli F-15I being able to carry 16 SPICE 250s, but nothing with same capability was added to F-15E. The GBU-53/B is a close counterpart for SPICE 250, with a different warhead.
GBU-53/B IR should be added for F-15E, as US currently has no counterpart to SPICE 250 other nations have on EF-2000, F-15I and JAS-39s.